Analgesic Efficacy of Nefopam in Patients Undergoing Kidney Transplantation

Yonsei University

Status: Completed

Conditions: Kidney Transplantation

Treatments: Drug: Nefopam; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01622881

4-2012-0173

Details and patient eligibility

About

The investigators examined the efficacy of nefopam in patients undergoing kidney transplantation.

Full description

Drug combination are frequently used to relieve postoperative pain. Nefopam can inhibit serotonin, dopamine, and norepinephrine reuptake through central mechanisms. Several studies have demonstrated analgesic efficacy of nefopam in the postoperative period. The purpose of this study is to ascertain the analgesic effect and tolerance of intravenous nefopam in combination with fentanyl based patient-controlled analgesia after kidney transplantation.

Enrollment: 98 patients

Sex: All

Ages: 20 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective living donor kidney transplantation

Exclusion criteria

• pre-operative tachycardia (> 100bpm)
• liver dysfunction
• severe cardiac disease
• body mass index ≥ 30 kg/m2
• drug allergy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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98 participants in 2 patient groups, including a placebo group

Nefopam

Active Comparator group

Treatment:

Drug: Nefopam

Control

Placebo Comparator group

Treatment:

Drug: Normal saline