Analgesic Use for Pain Relief in Scorpion Sting

Adiyaman University Research Hospital

Status: Completed

Conditions: Scorpion Stings

Treatments: Drug: Placebo; Drug: Lidocaine topical; Drug: paracetamol; Drug: Dexketoprofen Trometamol

Study type: Interventional

Funder types: Other

Identifiers

NCT05125796

2019-5-1

Details and patient eligibility

About

In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.

Full description

Aim: In this study, the analgesic efficacy of intravenous (IV) paracetamol, IV dexketoprofen trometamol and topical lidocaine will be compared in patients presenting with pain after scorpion sting.

Methods: This study is a double-blind, randomized, placebo-controlled study conducted in a tertiary emergency department. Adult patients who applied to the study with no systemic findings after scorpion sting and especially with pain will be randomly assigned to one of 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine or placebo. In order to determine the intensity of pain, Visual Analog Pain Score (VAS) will be measured at the time of admission to the emergency department, at the 30th minute and at the 60th minute. Afterwards, the VAS score changes between the groups will be compared.

Enrollment: 106 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 and over
• Scorpion sting with pain
• The diagnostic criteria of Grade 1 for Scorpion sting

Exclusion criteria

• Patients who denied to give informed consent
• Taking analgesic treatment (ice application or drugs etc.) in the last 6 hours
• Any symptoms and findings of systemic toxicity of scorpion sting
• Pregnant women
• Hemodynamically unstable patients
• Known allergy to drugs of the study
• Patients with renal disease
• The cases that passed more than 6 hours after the bite

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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106 participants in 4 patient groups, including a placebo group

paracetamol

Active Comparator group

Description:

1000 mg intravenous paracetamol

Treatment:

Drug: paracetamol

Dexketoprofen Trometamol

Experimental group

Description:

50 mg intravenous Dexketoprofen Trometamol

Treatment:

Drug: Dexketoprofen Trometamol

topical lidocaine

Experimental group

Description:

%5 lidocaine 5 gr topical

Treatment:

Drug: Lidocaine topical

placebo

Placebo Comparator group

Description:

100 mL intravenous normal saline+ placebo topical pomade

Treatment:

Drug: Placebo