Analysis of B Cells From Autoimmune Individuals

University of Colorado Denver (CU Denver) logo

University of Colorado Denver (CU Denver)

Status

Completed

Conditions

Type 1 Diabetes
Rheumatoid Arthritis
Lupus Erythematosus

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT02747277
16-0541
UL1TR001082 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells of individuals genetically susceptible to autoimmunity display defects in the biological process of tolerance, which removes B cells that participate in autoimmunity.

Full description

Peripheral blood B cells of SLE patients are analyzed by flow cytometry to determine the frequency of B cells co-expressing immunoglobulin kappa an lambda light chains. This frequency is correlated to the disease activity.

Enrollment

46 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult Males and Females diagnosed with Lupus;

Adult Females who are pregnant and diagnosed with:

  • lupus erythematosus
  • rheumatoid arthritis, or
  • type 1 diabetes.

Exclusion criteria

Adult males or adult females treated with B-cell depletion therapies.

Trial contacts and locations

1

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Central trial contact

Roberta Pelanda, PhD

Data sourced from clinicaltrials.gov

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