Analysis of Biopsies With Antibody Mediated Rejection According to the Therapy Response

Thomas Mueller

Status

Unknown

Conditions

Antibody-mediated Rejection

Treatments

Diagnostic Test: Transcriptome Analysis

Study type

Observational

Funder types

Other

Identifiers

NCT03430414

BASEC-Nr. 2017-02130

Details and patient eligibility

About

In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria and Banff-classification. Twenty-five patients will be selected each in the therapy-responder and non-responder group. Their stored Formalin Fixed Paraffin Embedded (FFPE) biopsies will be (re)-classified according to the most recent Banff classification. Using Nanostring Technology the gene transcription of therapy-responders versus non-responders will be analyzed and compared to serological and clinical parameters.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Kidney transplant patients at the University Hospital of Zurich between 01.01.2008 - 31.12.2016 with histologically suspected or confirmed ABMR
Written consent for further use of data for research purposes

Exclusion criteria

Age at transplantation < 18 years
Combined organ transplantation (incl. Kidney-Pancreas, Kidney-Liver, Kidney-Heart)
Incomplete laboratory and/or clinical data
Recurrence of the initial disease
Insufficient Biopsy Material for NanoString Analysis
Documented refusal of further data analysis for research purpose