Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

Jagiellonian University

Status: Completed

Conditions: Hyperthyroidism; Hypothyroidism; Graves Disease; Hashimoto Disease

Treatments: Diagnostic Test: Serum BPA

Study type: Observational

Funder types: Other

Identifiers

NCT04682340

BPA-Thyroid

Details and patient eligibility

About

The aim of the study is to assess the relationship between the concentration of bisphenol A in serum and selected parameters of thyroid function in women of reproductive age with thyroid dysfunction - Hashimoto's disease and Graves' disease.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Graves' disease or Hashimoto's disease (positive thyroid autoantibody)
• Control group: thyroid autoantibody negative, normal thyroid function
• Women aged 18 to 45 in both the control group and experimental group

Exclusion criteria

• Pregnancy and lactating women
• Previous or planned treatment with 131I or thyroidectomy
• The use of drugs affecting the thyroid function (lithium, amiodarone, interferon a, sodium nitroprusside, sunitinib, sorafenib, iodine contrast, antibiotics / antifungals / antivirals (for at least 4 weeks prior to recruitment to the study), which do not result from the treatment of thyroid disease (levothyroxine, thyreostatic drugs, glucocorticoids)
• Active malignancy
• Other autoimmune diseases
• Other endocrine diseases
• Patients with severe liver, kidney or heart failure

Trial design

80 participants in 3 patient groups

Hashimoto's Group

Description:

Thyroid antibody positive and hypothyroidism

Treatment:

Diagnostic Test: Serum BPA

Graves' Group

Description:

Thyroid antibody positive and hyperthyroidism

Treatment:

Diagnostic Test: Serum BPA

Control Group

Description:

Thyroid antibody negative and euthyroidism

Treatment:

Diagnostic Test: Serum BPA