Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject. (Volatopnee)

Hopital Foch

Status: Completed

Conditions: Healthy Subjects

Treatments: Other: VOCs analysis in exhaled air

Study type: Interventional

Funder types: Other

Identifiers

NCT04418973

2019_0074

Details and patient eligibility

About

The dyspnea is a common symptom in patients with many respiratory diseases particularly chronic obstructive airway diseases, but also cardiovascular pathologies, obesity, or also in the deconditioned healthy subjects.

Called volatolom corresponds to the set of volatile organic compounds (VOCs) contained in exhaled air.

The analysis of volatolom can be done either by the methods based on mass spectrometry which allows the identification of each VOC in the exhaled air or by the use of electronic noses which are more simple to use, less specific and produce a quantitive signal change based on pattern recognition algorithms providing a global profile of the VOC without identifying them.

The aim of the study is to determine whether the analysis of VOCs in exhaled air would identify biomarkers related to the intensity and type of experimental dyspnea.

Enrollment: 41 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subject
• no dyspnea
• non smoking or daily smoking more than 5 years packs
• perfect knowing of the French language
• the consent form signed
• affiliated to a health insurance plan

Exclusion criteria

• chronic disease
• history of asthma or Chronic obstructive pulmonary disease (COPD)
• personal or family atopy
• cannabis use
• electronic cigarette
• medication except contraception
• pregnant woman
• without liberty or guardianship

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 2 patient groups

A - load/apnea

Experimental group

Description:

Threshold inspiratory load then apnea

Treatment:

Other: VOCs analysis in exhaled air

B- apnea/load

Experimental group

Description:

apnea than threshold inspiratory load

Treatment:

Other: VOCs analysis in exhaled air