Analysis of Circulating Epithelial Tumor Cells in Peripheral Blood in Patients With Primary Non-metastatic Breast Cancer Under Adjuvant Radiotherapy

University of Jena

Status: Completed

Conditions: Breast Cancer Female

Treatments: Radiation: radiation

Study type: Observational

Funder types: Other

Identifiers

NCT03935802

CETC 001

Details and patient eligibility

About

The aim of this study was to investigate the systemic effect of radiotherapy on patients with primary non-metastatic breast cancer using CETC and to analyze possible changes in CETC quantity under adjuvant radiotherapy.

Full description

In cooperation with the Women's Hospital of the Friedrich Schiller University in Jena, a total of 161 patients with clinically proven, primarily non-metastatic breast cancer were sampled and examined before and after radiotherapy over a period from 09/2002 to 09/2012. The MAINTRAC method was used to quantitatively determine the amount of CETC in the blood and to observe its peritherapeutic course.

Enrollment: 161 patients

Sex: Female

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed invasive breast carcinoma
• age >= 18 years
• exclusive treatment at the Jena University Hospital
• complete curative-intended adjuvant or definite radiotherapy
• at least 2 blood collections (before the start of therapy, after the end of the RT)

Exclusion criteria

• presence of metastases
• recurrence
• DCIS, inflammatory breast cancer
• second malignancy <10 years before diagnosis of breast cancer
• radiotherapeutic pretreatment

Trial design

161 participants in 1 patient group

primary non-metastatic breast cancer

Description:

primary non-metastatic breast cancer

Treatment:

Radiation: radiation