Analysis of Clinical Characteristics and Study of Diagnostic Markers in Patients with Polycystic Ovary Syndrome

Tongji University

Status: Enrolling

Conditions: Polycystic Ovary Syndrome

Treatments: Other: This study does not involve any interventions

Study type: Observational

Funder types: Other

Identifiers

NCT05063383

Clinical Characteristics PCOS

Details and patient eligibility

About

The investigators collected clinical data and serum samples of patients with polycystic ovary syndrome in this study, used statistical software such as SPSS for data analysis, and used experimental techniques such as ELISA to detect serum samples, aiming to explore the relationship between the body anthropometry, glucose and lipid metabolism, gonadal hormones and body fat distribution in patients with polycystic ovary syndrome and to discovery new biomarkers and promote the realization of more accurate personalized medicine.

Enrollment: 600 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female aged 18- 45;
• Meet Rotterdam criteria;

Exclusion criteria

• Women who are pregnant or have a pregnancy plan within six months;
• Congenital adrenocortical hyperplasia;
• Hyperprolactinemia;
• Hyperthyroidism or hypothyroidism;
• Abnormal liver function (≥ 3 times of the upper limit of normal range);
• Abnormal renal function (GFR<60ml/min/1.73m2);
• Adrenal or ovarian tumors secreting androgens;
• Used contraceptives, metformin, GLP-1RA, pioglitazone and contraceptives in the last 3 month.

Trial design

600 participants in 2 patient groups

PCOS

Description:

1. Oligomenorrhea/amenorrhea 2. Clinical androgen excess or biochemical androgen excess 3. Polycystic ovary showed by gynecological ultrasound

Treatment:

Other: This study does not involve any interventions

NOPCOS

Description:

not meet Rotterdam standards

Treatment:

Other: This study does not involve any interventions