Analysis of CMTM6 Expression in Patients With Acute Myeloid Leukemia

University of Freiburg

Status: Completed

Conditions: Acute Myeloid Leukemia, Adult

Study type: Observational

Funder types: Other

Identifiers

NCT05988047

CMTM6_AML

Details and patient eligibility

About

In this study, we aim to investigate the expression of CKLF like MARVEL transmembrane domain containing 6 (CMTM6) in leukemia cells of patients with acute myeloid leukemia (AML). We will use peripheral blood samples and assess CMTM6 expression by flow cytometry and Western Blot.

Enrollment: 150 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 years
• primary diagnosis of acute myeloid leukemia
• diagnosis results available
• written informed consent
• ability to understand the nature of the study and the study related procedures and to comply with them

Exclusion criteria

• age < 18 years
• lack of informed consent

Trial design

150 participants in 2 patient groups

Patients with AML

Description:

Peripheral blood will be taken at the timepoint of primary diagnosis and analyzed for CMTM6 expression and T cell activation

Healthy controls

Description:

Peripheral blood will be taken analyzed for CMTM6 expression and T cell activation