Analysis of Inflammation in the Vitiligo and Other Inflammatory Skin Diseases: Psoriasis, Atopic Dermatitis and Alopecia Areata (INFLAMMAVit)

University Hospital of Bordeaux

Status: Unknown

Conditions: Atopic Dermatitis; Psoriasis; Vitiligo; Alopecia Areata

Treatments: Biological: Blood samples; Biological: Skin biopsies

Study type: Observational

Funder types: Other

Identifiers

NCT03976622

CHUBX 2017/55

Details and patient eligibility

About

It is a study of translational research with mechanistically objectives and including biological samples of patients with chronic inflammatory disorders

Full description

This study was a single-center prospective study to collect blood and skin tissue at the time of consultation with a patient with non-segmental vitiligo, psoriasis, atopic dermatitis or alopecia areata, in order to better understand and compare blood and skin immune response in chronic inflammatory skin disorders: psoriasis, alopecia areata, atopic dermatitis and vitiligo.

Enrollment: 450 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 to 75 years;
• Patients with non-segmental vitiligo;
• Patients with plaque psoriasis;
• Patients with atopic dermatitis;
• Patients with alopecia areata sclerosis;
• written consent, free, informed and signed by the patient and the investigator (before any examination required by the study);
• Subject affiliated or beneficiary of a social security system.

Exclusion criteria

• Patients with segmental vitiligo
• Patients under local treatment (topical corticosteroid-Calcineurin inhibitor) for less than two weeks.
• Patients on therapy, systemic treatments: acitretin, methotrexate, cyclosporine, Apremilast, infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, dupilumab) for less than 4 weeks.
• Pregnant or breastfeeding women
• Patient (e) under guardianship
• Patient (e) Non-affiliated (e) a social protection

Trial design

450 participants in 4 patient groups

vitiligo

Description:

Patients aged 18 to 75 years with non-segmental vitiligo;

Treatment:

Biological: Skin biopsies

Biological: Blood samples

psoriasis

Description:

Patients aged 18 to 75 years with plaque psoriasis;

Treatment:

Biological: Skin biopsies

Biological: Blood samples

atopic dermatitis

Description:

Patients aged 18 to 75 years with atopic dermatitis;

Treatment:

Biological: Skin biopsies

Biological: Blood samples

alopecia areata

Description:

Patients aged 18 to 75 years with alopecia areata sclerosis;

Treatment:

Biological: Skin biopsies

Biological: Blood samples