Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination

IVI Bilbao

Status: Withdrawn

Conditions: Primary Infertility

Study type: Observational

Funder types: Other

Identifiers

NCT02704936

505-BIO-035-MF

Details and patient eligibility

About

Identify, by Lipidomics approaches, biochemical markers of fertility / infertility in sperm and seminal plasma linking the success or failure of the artificial insemination (IUI)

Full description

Analyze lipid profiles in samples of sperm and seminal plasma of three populations:

1. male sperm donors
2. men assigned to a program of assisted reproduction with normal sperm / slightly abnormal successfully in the IUI;
3. attached to a program of assisted reproduction with male semen Normal / slightly abnormal unsuccessfully in IUI

Establish partnerships between the composition of fatty acids, especially fatty acids polyunsaturated (PUFA) of the omega-3 (w3) series of samples analyzed parameterssemen and results of the IA to identify biochemical markers of fertility.

Assess markers found by checking the increase in the rate of success in the IA.

Sex: Female

Ages: 18 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Group A women donor group

• Fallopian unobstructed Men donor group
• Appear as sperm donor
• Age between 18-35 years
• Sexual abstinence 3-5 days

Exclusion Criteria Group A:

• Uterine malformations (fibroids, adenomyosis, uterine malformations or acquired congenital) and fallopian tubes (tubal occlusion)
• Obesity BMI (Body Mass Index)> 30 kg / m2
• Presence of altered tubal toxic habits (smoking> 15 cigarettes per day, alcohol or drug abuse).

Inclusión / Exclusion Criteria Group B and C:

• ≤ 38 years
• Natural cycles and stimulated
• The criteria inclusion / exclusion group A
• Time sterility not exceeding three years.

Trial design

0 participants in 3 patient groups

Male donor

Description:

42 samples of semen from male donor attached to a donation program Normal sperm count as WHO 2010.

IUI positive pregnancy

Description:

42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and have obtained positive pregnancy in any of the first 4 treatments IUI

IUI unsuccessful pregnancy

Description:

42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and after undergoing maximum 4 cycles have unsuccessfully IUI indication of IVF / ICSI.