Analysis of Metabolic State in Normal-weight and Overweight-obese After Lifestyle Improvement and/or Weight Loss (METAHEALTH)

University of the Balearic Islands

Status: Completed

Conditions: Overweight and Obesity

Treatments: Other: Dietary and physical activity intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT04402697

nºIB 3216/16 PI

Details and patient eligibility

About

The aim of this study is to design and validate a test, METAHEALTH-TEST, based in gene expression analysis in blood cells, to quickly and easily analyse metabolic health. This test will be used to analyse metabolic improvement in overweight/obese individuals and in metabolically obese normal-weight (MONW) individuals after undergoing a weight loss intervention and/or an intervention for improvement in eating habits and lifestyle.

Enrollment: 80 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18-45 years
• Participants with no chronic disease (excluding those related to overweight/obesity)

Exclusion criteria

• Minors or older than 45 years
• Presence of a metabolic illness
• Intake of regular medication or drugs
• Precedents of alcohol or drug consumption
• Physic of psychic disability

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 3 patient groups

Normal-weight (NW)

No Intervention group

Description:

Individuals with BMI\<25 kg/m2

Overweight-Obese (OW-OB)

Experimental group

Description:

Individuals with BMI\>25 kg/m2, submitted to a nutritional intervention (hypocaloric balanced diet) during 6 months and prescription of physical activity to achieve weigh loss

Treatment:

Other: Dietary and physical activity intervention

Metabolically obese normal-weight (MONW)

Experimental group

Description:

Individuals with BMI\<25 kg/m2, with metabolic alterations related to obesity (hypertriglyceridemia, hypercholesterolemia, hyperglycaemia, hypertension or high waist-hip ratio), submitted to an intervention to improve dietary habits and physical activity in order to achieve a better body composition and metabolic health. Mediterranean diet will be and aerobic and strength exercises will be advised to these individuals.

Treatment:

Other: Dietary and physical activity intervention