Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement. (Vieillissement)

University Hospital Center (CHU) Dijon Bourgogne

Status: Enrolling

Conditions: Mild Cognitive Disorder

Treatments: Other: Sequence 1; Other: Sequence 2; Other: Sequence 3

Study type: Observational

Funder types: Other

Identifiers

NCT04754906

MANCKOUNDIA 2018

Details and patient eligibility

About

Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.

Enrollment: 684 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Neurotypical subjects group:

   • Person aged 18 to 40 years
   • Person who has given oral consent
   • Affiliated to national health insurance
   • Right-handed person

2. Group of elderly neurotypical subjects:

   • Person over 55 years of age
   • Person who has given oral consent
   • Affiliated to national health insurance
   • No cognitive problems (MMSE score >26)
   • Right-handed person

3. Elderly mild cognitive disorder subject group:

   • Person over 55 years of age
   • Person who has given oral consent
   • Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.
   • Right-handed person

Exclusion criteria

• Neurological or psychiatric history with the exception of the TCL group.
• Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.
• Received a shoulder prosthesis on the dominant side.
• Received a hip and/or knee replacement less than a year ago.
• Disabling joint disease of the hip or knee shoulder
• Protected adults (curatorship, guardianship)
• Person deprived of their liberty b judicial or administrative decision
• Pregnant, parturient or breastfeeding woman
• Major unable to consent

Trial design

684 participants in 3 patient groups

young neurotypical subjects

Description:

people from 18 to 40 years old

Treatment:

Other: Sequence 3

Other: Sequence 2

Other: Sequence 1

elderly neurotypical subjects

Description:

people over 55 years of age

Treatment:

Other: Sequence 3

Other: Sequence 2

Other: Sequence 1

Elderly subjects with mild cognitive impairment

Description:

people over 55 years of age, with a diagnosis of mild cognitive impairment

Treatment:

Other: Sequence 3

Other: Sequence 2

Other: Sequence 1