Analysis of NfL and GFAP in Different Dietary Patterns

Salzburger Landeskliniken

Status: Enrolling

Conditions: GFAP; Glial Fibrillary Acidic Protein; Vegetarian Diet; Vegan Diet; Neurofilament Light Chain

Study type: Observational

Funder types: Other

Identifiers

NCT07312994

1119/2025

Details and patient eligibility

About

This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.

The primary research question is: Do vegan, vegetarian, or omnivorous diets influence NfL and GFAP levels?

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy individuals who have followed a vegan, vegetarian, or omnivorous diet for at least one consecutive year
• Aged between 18 and 40 years
• Provision of written informed consent

Exclusion criteria

• Diagnose neurological disorders (e.g. neurodegenerative, inflammatory, autoimmune, infectious, vascular)
• Eating disorders
• Excessive alcohol consumption
• Pregnancy
• Recent moderate to severe infection (within the past 12 weeks) , including SARS-CoV-2
• Recent trauma, injury, or surgery (within the past 12 weeks)
• Significant BMI fluctuations (>5 points) within the last year
• Patients who have been using Proton pump inhibitors (PPIs) for an extended period (e.g., 1 month).

Trial design

300 participants in 3 patient groups

Omnivore

Vegan

Vegetarian