Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Psychiatric Patients

Medical University of Bialystok

Status: Completed

Conditions: Suicidal Behaviour; Cognitive Functions Confusion

Treatments: Diagnostic Test: biochemical parameters; Diagnostic Test: cognitive function; Other: Interview questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT05803447

N/ST/ZB/17/003/3316

Details and patient eligibility

About

The aim of this study was to analyse the level of cognitive functioning of patients with history of suicidal behaviour suffering from depression and schizophrenia, and to evaluate their oxidative stress parameters and selected biochemical parameters on the basis of bloodwork.

Full description

The study was conducted among 120 patients hospitalized in the Department of Psychiatry of the UMB (Medical University of Białystok). Every participant gave their own voluntary and informed written consent. Blood parameters tests were performed in the Diagnostic Laboratory of the University's Clinical Hospital and in the Department of Hygiene, Epidemiology and Ergonomics of the Medical University of Białystok. In the first stage of the study, an M.I.N.I. 7.0.2 interview was conducted with each patient to verify the intensification of suicidal behaviour. Based on the scores, the patients were classified into one of eight groups: no suicidal behaviour group (G0K, G0M); group experiencing suicidal thoughts without a tendency of implementation (G1K, G1M); group experiencing suicidal thoughts with a tendency of implementation (G2K, G2M); group after a suicide attempt (G3K, G3M).The second stage of the study consisted of biochemical blood tests, where concentrations of vitamin D3, B12, folic acid, sodium, potassium, calcium, magnesium, chlorine, total cholesterol, LDL and HDL fractions, TG and metabolites of the oxidative stress pathway were determined. The following concentrations were determined: dityrosine (AUF/mg protein), TOS (nmol H2O2 Equiv/mg protein), TAC (umol/mg protein), OSI (TOS/TAC ratio), FRAP (μmol/mg protein), GPx (mU/mg protein), SOD (mU/mg protein) CAT (nmol H2O2/min/mg protein), AOPP (nmol/mg protein), NO (nmol/mg protein), GSH (μg/mg protein). The third stage of the study consisted of the participants completing a CogState computerized test to verify their cognitive functioning. The following cognitive functions were assessed: psychomotor drive (DET), metastability of attention (IDN), verbal memory, retrieval of learned material (ISLR) and verbal learning and memory (ISL), visual learning and memory (OCL), processing speed (GMCT), visual memory including deferred retrieval (GMR), executive functions (SETS and GML), working memory (ONB, TWOB).

Enrollment: 120 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients of clinical psychiatry
• patients diagnosed with schizophrenia and depression
• age: 20-50 years
• gender: women and men

Exclusion criteria

• exclusion criteria were any present major medical illness (somatic or neurological disease)
• use of psychoactive substances
• decreased level of cognitive functioning
• people who do not use a computer

Trial design

120 participants in 8 patient groups

G1K-women

Description:

The G1K group consisted of women experiencing suicidal thoughts without a tendency of implementation, in whom the result of M.I.N.I. 7.0.2 test was 1 to 8 points (n=14)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G1M-men

Description:

The G1M group consisted of men experiencing suicidal thoughts without a tendency of implementation, in whom the result of M.I.N.I. 7.0.2 test was 1 to 8 points (n=16)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G2K-women

Description:

The G2K group consisted of women experiencing suicidal thoughts with a tendency of implementation, in whom the result of M.I.N.I. 7.0.2 test was 9 to 16 points (n=19)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G2M-men

Description:

The G2M group consisted of men experiencing suicidal thoughts with a tendency of implementation, in whom the result of M.I.N.I. 7.0.2 test was 9 to 16 points (n=9)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G3K-women

Description:

The G3K group consisted of women after a suicide attempt, in whom the result of M.I.N.I. 7.0.2 test was equal to or greater than 17 points (n=15)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G3M-men

Description:

The G3M group consisted of men after a suicide attempt, in whom the result of M.I.N.I. 7.0.2 test was equal to or greater than 17 points (n=17)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G0K-women

Description:

The G0K group consisted of women displaying no suicidal behaviour, in whom the result of M.I.N.I. 7.0.2 test was zero points (n=10)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters

G0M-men

Description:

The G0M group consisted of men displaying no suicidal behaviour, in whom the result of M.I.N.I. 7.0.2 test was zero points (n=20)

Treatment:

Diagnostic Test: cognitive function

Other: Interview questionnaire

Diagnostic Test: biochemical parameters