Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia (DRU-EMO-K)

Universitätsklinikum Köln

Status: Completed

Conditions: Hypoxia, Altitude

Treatments: Procedure: Hypoxia

Study type: Interventional

Funder types: Other

Identifiers

NCT03823677

DRU-EMO-KOELN

Details and patient eligibility

About

This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.

Full description

This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.

15 different Groups are analysed: control Group, 5000ft Group, 8000 ft Group, 10000ft Group and 15000ft Group - all for 15, 30, and 60 minutes.

Enrollment: 250 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Helathy

Exclusion criteria

• Ear problems

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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250 participants in 15 patient groups

control group 15

No Intervention group

Description:

Protein expression and emotional test 15 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase

control group 30

No Intervention group

Description:

30 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase

control group 60

No Intervention group

Description:

60 minutes normoxia Interventions: Blood drawing 1 Minute before and 1 Minute after the pressure chamber Phase for Proteomic profiling with 2D-gels Emotional tests (tears, stroop, mood) during the pressure chamber phase

hypoxia 5000ft group 15

Experimental group

Description:

Intervention: 15 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 5000ft group 30

Experimental group

Description:

Intervention: 30 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 5000ft group 60

Experimental group

Description:

Intervention: 60 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 8000ft group 15

Experimental group

Description:

Intervention: 15 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 8000ft group 30

Experimental group

Description:

Intervention: 30 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 8000ft group 60

Experimental group

Description:

Intervention: 60 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 10000ft group 15

Experimental group

Description:

Intervention: 15 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 10000ft group 30

Experimental group

Description:

Intervention: 30 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 10000ft group 60

Experimental group

Description:

Intervention: 60 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 15000ft group 15

Experimental group

Description:

Intervention: 15 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 15000ft group 30

Experimental group

Description:

Intervention: 30 minutes hypoxia

Treatment:

Procedure: Hypoxia

hypoxia 15000ft group 60

Experimental group

Description:

Intervention: 60 minutes hypoxia

Treatment:

Procedure: Hypoxia