Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells

Heinrich-Heine University, Duesseldorf

Status: Completed

Conditions: Red Blood Cell; Peripheral Blood Mononuclear Cell; Endothelial NO-synthase

Study type: Observational

Funder types: Other

Identifiers

NCT02272530

Proteome

Details and patient eligibility

About

The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of cardiovascular diseases.

Enrollment: 200 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers
• Patients: stable coronary artery disease with accordingly endothelial dysfunction

Exclusion criteria

• acute inflammation (CRP>0,5 mg/dl, leucocyte >11000/dl)
• malignant diseases
• acute or terminated kidney disease
• relevant heart failure (NYHA III-IV)

Trial design

200 participants in 2 patient groups

Healthy

Description:

100 healthy volunteers in age of 20-75 years

Patients

Description:

100 patients with stable coronary artery disease and accordingly endothelial dysfunction