Analysis of Psychoneuroimmunological Parameters of Health in Specific Population Groups in Slovakia (APNIP)

Comenius University

Status: Active, not recruiting

Conditions: Depression Symptoms; Self-control; Anxiety Symptoms; Psychological Adaptation; Immunity; Stress Response; Psychological Distress; Problem Solving; Positive Thinking; Resilience; Sense of Control; Cytokine Levels; Mindfulness; Socio-economic Status; Adverse Childhood Experience; Stress; Sense of Coherence

Study type: Observational

Funder types: Other

Identifiers

NCT07070180

APVV-22-0160

Details and patient eligibility

About

This study aims to investigate the links between psychological and biological immunity from the perspective of psychology, epidemiology, and immunology in a general population study sample as well as in a specific group of people in treatment for alcohol addiction.

Full description

The study will explore the associations between the level of psychological immunity and the current psychological state of the participants, possible links between the level of psychological immunity in adulthood and adverse childhood experiences, and finally, the association between the psychological immunity and biological immunity expressed by the self- assessed perceived immune status and on a molecular level by quantity of cytokines and in a specific subgroup also by natural killer cells. All this will be studied in a sample of general population as well as in a specific group of people in treatment for alcohol addiction that was chosen based on the known adverse immune-related health effects of excessive alcohol consumption.

Enrollment: 700 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for 'General Slovak Population Sample':

• Age between 18 - 50 years
• Residency in the respective region for at least five years
• Consent to participate in the study

Exclusion Criteria for 'General Slovak Population Sample':

• Individuals younger than 18 or older than 50 years
• Ongoing acute infectious disease on the day of testing
• Eligible individuals who do not provide informed consent

Inclusion Criteria for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility':

• Age between 18 - 50 years
• Admission to treatment for alcohol addiction
• Consent to participate in the study, Treatment completion

Exclusion Criteria for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility':

• Individuals younger than 18 or older than 50 years
• Eligible individuals who do not provide informed consent
• Drop-out from alcohol addiction treatment

Trial design

700 participants in 2 patient groups

General Slovak population sample

Description:

Adults aged 18 to 50, with the upper age limit set to account for the natural decline in immune function beyond this age. A total of 600 participants were recruited from three regions: 300 from the Bratislava region, 150 from the Banská Bystrica region, and 150 from the Košice region.

Individuals receiving inpatient treatment for alcohol addiction at the treatment facility

Description:

100 participants aged 18 to 50 years who undergo psychological, epidemiological, and immunological assessments multiple time points - upon admission, during hospitalisation, and at the conclusion of treatment.