Analysis of Respiratory System Mechanics and Inflammatory Response During Orthotopic Liver Transplantation (SPPLIT Trial)

University of Turin

Status: Unknown

Conditions: End Stage Liver Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT02119585

0077687

Details and patient eligibility

About

During orthotopic liver transplantation (OLT), respiratory system function may be severely impaired for several reasons including anaesthesia effects, hyperdynamic volume state with fluid overload and ischemia reperfusion injury. In particular, reperfusion syndrome is characterised by the release of several inflammatory mediators such as cytokines and oxygen free radicals which may contribute to alveolar endothelial barrier dysfunction. The object of this study is to investigate the respiratory system mechanics impairment in its partitioning between lung and chest wall.

We hypothesize that impairment of respiratory system mechanics (of both lung and chest wall) occurs after reperfusion phase of liver. This impairment is associated with the systemic inflammatory response following liver reperfusion.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• orthotopic liver transplantation
• valid informed consent

Exclusion criteria

• Age < 18 yrs

Trial design

30 participants in 1 patient group

Patients undergoing OLT

Description:

insertion of nasogastric tube for measurements of chest wall mechanics