Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning

Nanjing University

Status: Active, not recruiting

Conditions: Diquat Poisoning; Toxic Encephalopathy

Treatments: Procedure: extracorporeal treatment

Study type: Observational

Funder types: Other

Identifiers

NCT06798142

2025-1047-02

Details and patient eligibility

About

This study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.

Enrollment: 193 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. history of oral exposure to diquat solution reported by patient or proxy;
2. a specimen for the diquat plasma concentration collected immediately upon admission;
3. documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans.

Exclusion criteria

1. they had ingested other toxins in addition to diquat (qualitative toxicological screening tests);
2. diquat was not detected in specimens, or plasma concentration data were unavailable;
3. patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours;
4. data on organ damage were not unavailable;
5. combined with other central nervous system injuries other than toxic encephalopathy.