Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death (ASGARD)

University Hospital Muenster

Status: Unknown

Conditions: Endothelial Dysfunction; Septic Shock; Sepsis

Treatments: Other: Endothelial Glycocalyx

Study type: Observational

Funder types: Other

Identifiers

NCT03847493

ASGARD

Details and patient eligibility

About

The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU patients admitted to the ICU with the clinican suspicion of sepsis/septic shock.

Exclusion criteria

• Underage persons, pregnant women, patients with inflammation or trauma of sublingual mucosa.

Trial design

100 participants in 2 patient groups

Patients with suspected sepsis

Description:

Patients admitted in the ICU with the clinical suspicion of infection/sepsis.

Treatment:

Other: Endothelial Glycocalyx

Non-sepsis Patients (control group)

Description:

Patients admitted in the ICU with other conditions apart from infection/sepsis.

Treatment:

Other: Endothelial Glycocalyx