Analysis of T Cell Metabolism in Acute Myeloid Leukemia Patients

University of Freiburg

Status: Completed

Conditions: Acute Myeloid Leukemia

Study type: Observational

Funder types: Other

Identifiers

NCT04259372

Tmet_AML

Details and patient eligibility

About

The objective of this study was to analyze the T cell metabolism and immune phenotype in AML patients during the course of the disease before and after allo-HCT.

Full description

Patients who experience relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (allo-HCT) have a dismal prognosis. Infusion of donor T cells can induce graft-versus-leukemia (GVL) effects, indicating the importance of intact T cell function for leukemia control. Recent studies have shown the importance of metabolic fitness for an effective T cell response.

In this study we have analyzed the T cell metabolism and immune phenotype in AML patients at different time points before and after allo-HCT.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• confirmed diagnosis of AML
• age ≥ 18 years
• peripheral blood sample available
• written informed consent
• ability to understand the nature of the study and the study related procedures and to comply with them

Exclusion criteria

• age < 18 years
• lack of informed consent
• patients that cannot be classified in one of the 3 groups

Trial design

77 participants in 3 patient groups

Primary Diagnosis

Description:

Analysis of patient blood at primary diagnosis of AML

Relapse

Description:

Analysis of patient blood at time point of relapse after allo-HCT

Remission

Description:

Analysis of patient blood during remission after allo-HCT