Analysis of the Dynamics of the Lung Microbiota During Acute Exacerbation of COPD Requiring Admission to Intensive Care Unit (ADMiRE)

University Hospital of Bordeaux

Status: Unknown

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Biological: Sputum collection

Study type: Observational

Funder types: Other

Identifiers

NCT03641235

CHUBX 2018/17

Details and patient eligibility

About

This study aims to investigate the correlation between pulmonary microbiota dynamics (including bacteria, fungi and viruses) and COPD exacerbation for COPD patients admitted to ICU

Full description

Chronic obstructive pulmonary disease (COPD) is a frequent cause of ICU admission. COPD exacerbations are a leading cause of lung function worsening and of morbimortality. Hospitalizations due to COPD exacerbations are highly expensive for health insurance system. Bacterial pulmonary microbiota has been shown to be correlated to the severity of COPD and to exacerbations. Nevertheless fungi and viruses which are full actors of pulmonary microbiota have not yet been investigated.

Our primary outcome will be the assessment of alpha and beta diversity dynamics of the whole pulmonary microbiota (bacteria, fungi and viruses) between COPD exacerbation and steady state.

This study will prospectively include 24 patients at ICU admission for COPD exacerbation with sputum sampling. Steady-state as defined during a 2 months-later visit will be studied with another sputum collection.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patient above 18 admitted in ICU
• Admitted for COPD exacerbation defined by sustained (> 2 days) worsening of respiratory symptoms considering Anthonisen's criteria with life-threatening condition.
• Needing mechanical ventilation (noninvasive ventilation or oro-tracheal intubation)
• COPD condition will be presumed according to patient's respiratory history or previous lung function testing
• Able to consent or with the patient's family consent
• Affiliated to a social insurance scheme

No inclusion Criteria:

• COPD patient admitted for another cause than respiratory failure
• person under tutorship or curatorship
• living further than 100 kilometers away from the ICU
• expected survival inferior to 1 week

Exclusion Criteria

• Lung function testing not consistent with COPD at steady-state visit

Trial design

24 participants in 1 patient group

exacerbating COPD patients needing ICU admission

Description:

sputum collection

Treatment:

Biological: Sputum collection