Analysis of the Eye in Patients With Primary Open-Angle Glaucoma and a Visual Field Defect in One Eye

Wills Eye

Status: Completed

Conditions: Glaucoma

Treatments: Device: Spectral domain Optical Coherence Tomography

Study type: Interventional

Funder types: Other

Identifiers

NCT02622191

12-229

Details and patient eligibility

About

The study aims to further understand glaucoma pathogenesis and progression by utilizing enhanced depth imaging optical coherence tomography to visualize and measure lamina cribrosa in vivo and segmentation technology to accurately delineate and measure boundaries of the retinal layers. Investigators will elaborate further on key concepts of lamina cribrosa thickness and trans-synaptic degeneration.

Full description

Two important areas of the eye that need investigation in order to further understanding of glaucoma. First is the retina (part of the eye that converts images from the eye's optical system into electrical impulses sent along the optic nerve to the brain). Newer technology, Spectral Domain Optical Coherence Tomography (SD-OCT), allows us to look at different layers of the retina and carefully measure thickness of each layer. Second area is lamina cribrosa (a portion of the white part of the eye which has nerve fibers passing through it connecting the eye to the brain). If lamina cribrosa is thin, it is possible it may bend easily and disrupt nerve fibers. SD-OCT allows measurement of lamina cribrosa thickness.

Findings will help monitor changes that occur in the eye as a result of glaucoma.

Individuals with primary open-angle glaucoma and unilateral visual field defects were chosen as the main patient population (in addition to normal controls). By approximating each participants baseline anatomy using the fellow, "internal control" eye, investigators will be able to better determine if any changes occur in the macula or the lamina cribrosa as a result of glaucoma.

Enrollment: 33 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Best-corrected visual acuity of 20/40 or better
• No media opacities
• Spherical equivalent refractive errors in a range of -6 to +6 diopters
• Cylinder correction within 3.0 diopters.

Exclusion criteria

• Age < 18 years old
• Visual Acuity < 20/40
• Nuclear sclerosis > +2
• Corneal diseases
• Contact lens use
• History of posterior segment intraocular surgery
• Systemic or ocular diseases that can cause visual field loss.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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33 participants in 2 patient groups

Open-angle glaucoma

Experimental group

Description:

Participants with primary open-angle glaucoma and an abnormal visual field defect in one eye. Spectral domain Optical Coherence Tomography will be obtained from the effected eye and fellow eye of each glaucoma patient.

Treatment:

Device: Spectral domain Optical Coherence Tomography

Healthy Controls

Experimental group

Description:

Participants without glaucoma and no other eye diseases. Spectral domain Optical Coherence Tomography will be obtained from eyes of each healthy control.

Treatment:

Device: Spectral domain Optical Coherence Tomography