Analysis of the Impact of Cholecystectomy on Gut Microbiome in Adults

Shanghai Jiao Tong University School of Medicine

Status and phase: Unknown; Phase 1

Conditions: Laparoscopic Cholecystectomy

Treatments: Procedure: Laparoscopic cholecystectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT03836170

rjkls20190208

Details and patient eligibility

About

Laparoscopic cholecystectomy (LC) is widely used in the gallbladder stone, gallbladder polyp, gallbladder cancer and other diseases. Some of the patients would develop diarrhea after surgery, and studies have reported an increased risk of colorectal cancer after LC. The aim of the present study was to examine the effects of LC on the gut microbiota.

Enrollment: 40 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Gallbladder polyps diameter mm >10;
2. The history of the symptoms of patients with gallbladder stones, there was no history of acute attack in the past month;
3. Age <70 years old;
4. No serious systemic diseases such as diabetes, hypertension, heart disease, lung disease and so on/American anesthesia Association (ASA) grade I or II;
5. BMI<30;
6. Families have better care and observation, and away from the hospital within 1 hours; patients and their families understand the process of ambulatory surgery (24 hours) and the pros and cons.

Exclusion criteria

1. Less than 18 years old;
2. With previous gastric surgery ;
3. Major systemic diseases ;
4. Pregnancy or lactation;
5. The use of antibiotics or yogurt within 2 months before the study.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Laparoscopic cholecystectomy

Experimental group

Description:

A laparoscopic cholecystectomy was performed to remove the gallbladder

Treatment:

Procedure: Laparoscopic cholecystectomy