Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid

Selcen Ozcan Bulut

Status: Completed

Conditions: Peridontal Disease; Periodontitis, Adult; Periodontal Inflammation

Study type: Observational

Funder types: Other

Identifiers

NCT07243145

2023/87

Details and patient eligibility

About

AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.

METHOD: The study comprised 80 nonsmoking, systemically healthy volunteers. Patients were divided into two groups at random: the Guided Biofilm Therapy (GBT) group and the convetional therapy group, which included Gracey curette and an ultrasonic device. All patients were assessed before and one and three months after therapy for clinical characteristics like pocket depth, Gingival Index (GI), Plaque Index (PI), Bleeding on Probing Index (BOP), and the levels of IL-1β, IL-10, TNF-α, and MMP-8 in gingival crevicular fluid (GCF).

RESULTS: ... CONCLUSION:...

Full description

AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.

METHOD: The study comprised 80 nonsmoking, systemically healthy volunteers. Patients were divided into two groups at random: the Guided Biofilm Therapy (GBT) group and the convetional therapy group, which included Gracey curette and an ultrasonic device. All patients were assessed before and one and three months after therapy for clinical characteristics like pocket depth, Gingival Index (GI), Plaque Index (PI), Bleeding on Probing Index (BOP), and the levels of IL-1β, IL-10, TNF-α, and MMP-8 in gingival crevicular fluid (GCF).

RESULTS: ... CONCLUSION:...

Enrollment: 80 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemically healthy (no known chronic diseases)
• Completed periodontal diagnostic data (Gingival Index, Plaque Index, Periodontal pocket depths, Attachment loss, Radiological data, and Bone loss data)
• Did not take anti-inflammatory drugs in the previous month
• Volunteered to participate with Stage 1-2 periodontitis.

Exclusion criteria

• Patients with systemic diseases
• Pregnant or lactating patients
• Smokers
• Patients who did not wish to participate in the study were excluded

Trial design

80 participants in 2 patient groups

1.Group: The Conventional Treatment

Description:

Cavitron and Gracey curette (the standard technique) was utilized for subgingival debridement

2. group: Guided biofilm therapy

Description:

Subgingival debridement was carried out using the GBT approach, which involved following the protocol's directions properly.