Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults

Shanghai Jiao Tong University School of Medicine

Status and phase

Unknown

Phase 4

Conditions

Helicobacter Pylori Infection

Treatments

Drug: Esomeprazole

Drug: Bismuth Potassium Citrate

Drug: Amoxicillin

Study type

Interventional

Funder types

Other

Identifiers

NCT03730766

rjyy20180801

Details and patient eligibility

About

Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H. pylori in oral cavity and its influence on oral microbiota remains to be unclear. The aim of the present study was to examine the effects of H. pylori infection as well as its eradication on oral microbiota.

Enrollment

60 estimated patients

Sex

All

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participants with non-ulcer functional dyspepsia or peptic ulcer disease
Ability and willingness to participate in the study and to sign and give informed consent
Received both endoscopy and 13C urea breath test (13C-UBT) before enrolled

Exclusion criteria

Less than 18 years old
With previous gastric surgery
Major systemic diseases
Pregnancy or lactation
Allergy to any of the study drugs Administration of antibiotics, bismuth, antisecretory drugs in 8 weeks prior to inclusion
The use of antibiotics or PPI within 2 months before the study
The presence of dental carious or any untreated cavitated carious lesions and oral abscesses