Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19

C

Coordinación de Investigación en Salud, Mexico

Status

Unknown

Conditions

SARS-CoV-2

Treatments

Other: Active COVID-19 disease

Study type

Observational

Funder types

Other

Identifiers

NCT04423640
R-2020, 3601-043

Details and patient eligibility

About

The SARS-CoV-2 infection in the airway epithelium induces cytopathic effects and the cessation of ciliary movement. Increased cytokines and chemokines have been reported to be associated with the severity of the disease. However, most of the molecular and cellular aspects of the inflammatory response and the processes of development of humoral and cellular immunity in these patients are unknown. The aim of this study is characterizing inflammatory processes, seeking to expand the knowledge of the cellular and molecular pathophysiology of COVID-19 that could help in the decision-making of treating health personnel. Mainly, the study is focused on analyzing the inflammatory response by determining cytokines and chemokines. Also, the viral load of the patients with COVID-19 will be determined and will be correlated with the antibody titers. On the other hand, cells will be immunophenotyped to search the cellular depletion profile. Finally, an epidemiological analysis of the patients will be carried out.

Enrollment

200 estimated patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients over 16 years old with positive molecular diagnosis of Covid-19, in the Laboratory of IMSS

Exclusion criteria

  • Patients with immunosuppressive diseases: HIV +, Hepatitis C virus, primary immunodeficiencies, rheumatoid arthritis, lupus erythematosus and patients under treatment with immunosuppressants

Trial design

200 participants in 1 patient group

COVID Patients
Description:
Diagnosed patients with COVID-19 by PCR
Treatment:
Other: Active COVID-19 disease

Trial contacts and locations

1

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Central trial contact

Eduardo Ferat-Osorio, PhD; Constantino López Macías, PhD

Data sourced from clinicaltrials.gov

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