Analysis of the Influence of Desensitizing Treatments on the Pulp Inflammatory Response in Bleached Teeth

Universidade Federal do Para

Status: Completed

Conditions: Pulp Inflammation

Treatments: Device: Whiteness HP 35% + LASER; Other: Whiteness HP 35% + CPP; Other: Whiteness HP 35% + NANO; Other: Whiteness HP 35%

Study type: Interventional

Funder types: Other

Identifiers

NCT04548674

UFPara-008

Details and patient eligibility

About

This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).

Full description

Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n = 6): CN (negative control): without intervention; CP (Positive control): PH; PMB: PH + photobiomodulation with low power laser; CPP: PH + casein phosphopeptide phosphopeptide amorphous calcium phosphate (CPP-ACPF); NANO: PH + nanohydroxyapatite. The office whitening was performed in two sessions with a single application of 45 min and an interval of 48 hours between them. Pulp tissues were removed for immunohistochemical analysis. Immunostaining was performed for Caspase 3 using an Axio Scope.A1 microscope.

Enrollment: 18 patients

Sex: All

Ages: 20 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Lower third molars class I position A
• Maxillary third molars horizontal position A
• Absence of caries and enamel fracture
• Absence of periodontal disease
• Extraction of third molars for orthodontic reasons
• No allergy to the anesthetic and positive pulp sensitivity test

Exclusion criteria

• Calcification in the middle third of the root
• Drug users or smokers
• Patients who have already done whitening
• Root apex with incomplete formation and patients with systemic problems that would make surgery impossible

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Single Blind

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18 participants in 5 patient groups, including a placebo group

Positive Control Group

Placebo Comparator group

Description:

Whiteness HP 35%

Treatment:

Other: Whiteness HP 35%

Laser Group

Experimental group

Description:

Whiteness HP 35% + Laser

Treatment:

Other: Whiteness HP 35%

Device: Whiteness HP 35% + LASER

CPP Group

Experimental group

Description:

Whiteness HP 35% + CPP

Treatment:

Other: Whiteness HP 35%

Other: Whiteness HP 35% + CPP

Nano Group

Experimental group

Description:

Whiteness HP 35% + NANO

Treatment:

Other: Whiteness HP 35%

Other: Whiteness HP 35% + NANO

Negative Control

No Intervention group

Description:

Without intervention