Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Active, not recruiting

Conditions: Preeclampsia

Treatments: Other: Blood samples for inflammatory markers

Study type: Interventional

Funder types: Other

Identifiers

NCT06873737

4299

Details and patient eligibility

About

Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.

Full description

The aim of this study is to analyze the levels of circulating placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia to investigate the potential role of HLA-DR as early biomarker.

Enrollment: 300 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant Women
• Aged > 18 years

Exclusion criteria

• age < 18 years
• women unable to give informed consent
• infectious diseases
• twin pregnancies

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

"High risk"

Experimental group

Description:

Blood sampling from women with high risk to develop preeclampsia in the first, second and third trimester of pregnancy

Treatment:

Other: Blood samples for inflammatory markers

Low risk

Experimental group

Description:

Blood sampling from women with low risk to develop preeclampsia in the first, second and third trimester of pregnancy

Treatment:

Other: Blood samples for inflammatory markers