Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy (CILTUBE)

Centre Hospitalier Intercommunal Creteil

Status: Enrolling

Conditions: Ectopic Pregnancy; Primary Ciliary Dyskinesia; Hysterectomy; Salpingectomy

Treatments: Procedure: salpingectomy; Procedure: hysterectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT05374720

CILTUBE

Details and patient eligibility

About

Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women

Full description

Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP.

Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU

Enrollment: 50 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with scheduled salpingectomy (Ectopic pregnancy, hysterectomy for prolapsus, adenomyosis or myomectomy)
• Major patients ( >18 years)

Exclusion criteria

• Patient not willing to participate in the study

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Salpingectomy for Extra-Uterine Pregnancy

Experimental group

Description:

patients with salpingectomy for Ectopic Pregnancy

Treatment:

Procedure: salpingectomy

hysterectomies

Sham Comparator group

Description:

patients with hysterectomy for prolapsus, adenomyosis or myomectomy

Treatment:

Procedure: hysterectomy