Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities (MFS)

Istituto Ortopedico Rizzoli

Status: Completed

Conditions: Sarcoma,Soft Tissue

Treatments: Other: case series review of clinical and histological data

Study type: Observational

Funder types: Other

Identifiers

NCT04991883

MFS

Details and patient eligibility

About

Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017.

The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.

Enrollment: 167 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male and female patients treated at Rizzoli Institute from 01 Jan 1993 to 01 Dec 2017
2. Diagnosis of mixofibrosarcoma of extremities
3. Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis and molecular analysis
4. Enough tumor biobanked material available for molecular analysis
5. Presence of the biobank signed informed consent
6. Written informed consent prior to any study-specific analysis and/or data collection

Exclusion criteria

1. Patients with histological diagnosis different from mixofibrosarcoma of extremities

Trial design