Analysis of the Role of IgE Proteoforms in Health and Disease (IgE-PhD)

Catholic University (KU) of Leuven

Status: Enrolling

Conditions: Healthy Control; Chronic Spontaneous Urticaria (CSU); Mastocytosis; Type I Allergy; Venom Allergy; X-linked Agammaglobulinaemia; Hereditary Alpha-Tryptasemia; Medication Allergy; Anaphylaxis

Treatments: Other: Blood sample collection

Study type: Observational

Funder types: Other

Identifiers

NCT07328178

S69940

Details and patient eligibility

About

The goal of this observational study is to evaluate the role of IgE proteoforms in healthy volunteers and in patients with type I allergy, patients with chronic spontaneous urticaria, patients with a recent history of anaphylaxis, patients with mastocytosis, patients with hereditary alpha tryptasemia, patients with X-linked agammaglobulinemia (XLA), and patients undergoing desensitization for venom or medication allergy.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• CSU and type I allergic diseases (including anaphylaxis and desensitization), atopic dermatitis, mastocytosis, XLA and HaT (informed consent, age: any available adult subject, gender: any available subject, clinical phenotype and specific information about the allergy (e.g. severity, medication, medical history, laboratory testing)
• Healthy controls (informed consent, age matched to the allergic patients, gender matched to the allergic patients, patient-reported symptoms related to allergy to aeroallergens, food, drugs, hymenoptera venom, CSU)

Exclusion criteria

• Absence of informed consent
• Age < 18 years old

Trial design

200 participants in 9 patient groups

Healthy controls

Treatment:

Other: Blood sample collection

Patients with type I allergy

Description:

Including medication allergy, venom allergy, food allergy, allergic rhinitis

Treatment:

Other: Blood sample collection

Patients with chronic spontaneous urticaria

Description:

With or without omalizumab

Treatment:

Other: Blood sample collection

Patients with a recent history of anaphylaxis

Description:

In whom serial sampling can be performed

Treatment:

Other: Blood sample collection

Patients undergoing desensitization for venom allergy

Treatment:

Other: Blood sample collection

Patients undergoing desensitization for medication allergy

Treatment:

Other: Blood sample collection

Patients with mastocytosis

Treatment:

Other: Blood sample collection

Patients with hereditary alpha tryptasemia

Treatment:

Other: Blood sample collection

Patients with X-linked agammaglobulinemia (XLA)

Treatment:

Other: Blood sample collection