Analysis of the Role of T-cell Response in Patients With Atrial Fibrillation for Clinical Application

Yonsei University

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Other: radio-frequency catheter ablation of atrial fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT02421900

4-2015-0090

Details and patient eligibility

About

The purpose of this study is 1) to characterize T-cell response in patients with atrial fibrillation, and 2) to analyze the changes of T-cell response after radio-frequency catheter ablation of atrial fibrillation. First, immune-phenotyping and cytokine profiling of T cells from patients with atrial fibrillation will performed. Next the difference of T-cell immunity among various type of atrial fibrillation patients will be analyzed. Finally the changes of T-cell response and cytokines after radio-frequency catheter ablation of atrial fibrillation will be assessed.

Enrollment: 100 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who consent with study
• patients with age more than19
• patients who undergoing catheter ablation of atrial fibrillation due to symptomatic, drug refractory atrial fibrillation

Exclusion criteria

• Patients who do not agree with study inclusion
• Permanent AF refractory to electrical cardioversion
• AF with rheumatic valvular disease
• Patients with left atrial diameter greater than 60mm
• Patients with age less than 19
• Patient with malignant tumor and chronic infection disease
• Patient are given immune inhibitor and steroidal anti-inflammatory drug within 2weeks

Trial design

100 participants in 1 patient group

group 1

Description:

Atrial fibrillation patients

Treatment:

Other: radio-frequency catheter ablation of atrial fibrillation