ANalyzing Olfactory Dysfunction Mechanisms In COVID-19 (ANOSMIC-19)

Universitaire Ziekenhuizen KU Leuven

Status: Enrolling

Conditions: SARS-CoV-2

Treatments: Other: Sampling of tissue

Study type: Interventional

Funder types: Other

Identifiers

NCT04445597

S64042

Details and patient eligibility

About

We aim to understand the mechanism of olfactory dysfunction in COVID-19.

Full description

In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization.

By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders.

In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.

Enrollment: 150 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively

Exclusion criteria

• none

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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150 participants in 1 patient group

COVID-19 positive or negative patients

Other group

Description:

Hospitalised patients with or without COVID-19 (with or without olfactory dysfunctions)

Treatment:

Other: Sampling of tissue