Analyzing the Changes in Eye Axis Length and Corneal Curvature in Central China

Min Ke

Status: Not yet enrolling

Conditions: Birth Year-dependent Eye Parameters Change

Treatments: Other: Birth year

Study type: Observational

Funder types: Other

Identifiers

NCT06126302

20231105

Details and patient eligibility

About

The Chinese lifestyle has undergone dramatic changes over the past century. In recent years, limited studies reported the changing trend in crucial eye parameters of people born in different decades. This multicenter study analyzed the axial length and average corneal curvature data from patients of four hospital. The trends in the axial length and corneal curvature will be observed.

Full description

The Chinese lifestyle has undergone dramatic changes over the past century. In recent years, limited studies reported the changing trend in crucial eye parameters of people born in different decades. This multicenter study analyzed the axial length and average corneal curvature data between 2012 and 2023. There were four clinical centers involved in this study. The study was approved by the Medical Ethics Committee of Zhongnan Hospital, Wuhan University, Yichang center hospital, Jingzhou center hospital , Yichang center hospital and Xiaogan center hospital, and conformed to the tenets of the Declaration of Helsinki. We divided the participants into ten groups of 10 years each based on their year of birth (called birth decade) and observed the trends in the axial length and corneal curvature in different groups.

Enrollment: 60,000 estimated patients

Sex: All

Ages: 7 to 130 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Eligible patients were those aged ≥7 years and who underwent intraocular lens (IOL) Master (version 5.5) biometry for routine examination of cataract or refractive examination (ametropia and presbyopia) between April 2012 and November October 2023. Only patients who would cooperate with examinations to ensure stable and repeatable data (AL was measured 5 times or more, CC was measured 3 times or more, and the coefficient of variation of the measured results were≤15%a coefficient of variation ≤15% was considered low variation) were selected.

Exclusion criteria

• Severe systemic disease, corneal diseases, severe dry eyes, serious fundus disease, noticeable lesions of the refractive stroma, inability to cooperate, or poor measurement quality (coefficient of variation> 15%) were the exclusion criteria.

Trial design

60,000 participants in 10 patient groups

Before 1930

Description:

the patients were divided into ten groups according to the decade of their birth: before 1930

Treatment:

Other: Birth year

1930-1939

Description:

the patients were divided into ten groups according to the decade of their birth: 1930-1939

Treatment:

Other: Birth year

1940-1949

Description:

the patients were divided into ten groups according to the decade of their birth: 1940-1949

Treatment:

Other: Birth year

1950-1959

Description:

the patients were divided into ten groups according to the decade of their birth: 1950-1959

Treatment:

Other: Birth year

1960-1969

Description:

the patients were divided into ten groups according to the decade of their birth: 1960-1969

Treatment:

Other: Birth year

1970-1979

Description:

the patients were divided into ten groups according to the decade of their birth: 1970-1979

Treatment:

Other: Birth year

1980-1989

Description:

the patients were divided into ten groups according to the decade of their birth: 1980-1989

Treatment:

Other: Birth year

1990-1999

Description:

the patients were divided into ten groups according to the decade of their birth: 1990-1999

Treatment:

Other: Birth year

2000-2009

Description:

the patients were divided into ten groups according to the decade of their birth: 2000-2009

Treatment:

Other: Birth year

after 2009

Description:

the patients were divided into ten groups according to the decade of their birth: after 2009

Treatment:

Other: Birth year