Anastomotic Leaks in Esophageal Squamous Cell Carcinoma Patients After Trimodal Therapy

Qiaoqiao Li

Status: Completed

Conditions: Anastomotic Leak Esophagus

Treatments: Other: neoadjuvant chemoradiation and McKeown esophagectomy

Study type: Observational

Funder types: Other

Identifiers

NCT06556355

202210172055000282645

Details and patient eligibility

About

To investigate the clinical factors and preoperative treatment to the future anastomotic location of cervical esophagus that were correlated with anastomotic leaks in esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoradiation and McKeown esophagectomy and to explore the prognosis of anastomotic leak.

Full description

The goal of this observational study is to investigate the clinical factors and preoperative treatment to the future anastomotic location of cervical esophagus that were correlated with anastomotic leaks in esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoradiation and McKeown esophagectomy and to explore the postoperative complications, mortality, and long-term survival of different types of anastomotic leak.

Enrollment: 218 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• histologically confirmed ESCC;
• clinically staged as T3-4aN0M0 or T1-4aN+M0 by the eighth edition of the American Joint Committee on Cancer and treated with nCRT followed by McKeown esophagectomy24;
• aged 18-75 years;
• Eastern Cooperative Oncology Group performance status score ≤ 2.

Exclusion criteria

• cervical esophageal cancer;
• previously treated with chest radiotherapy, esophageal, or gastric surgery;
• insufficient clinical data.

Trial design

218 participants in 1 patient group

Overall patients

Description:

Consecutive patients with locally advanced thoracic ESCC who underwent nCRT and surgery at our center between 1 January 2015 and 31 December 2020.

Treatment:

Other: neoadjuvant chemoradiation and McKeown esophagectomy