Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia

University Hospital, Strasbourg, France

Status: Completed

Conditions: Catatonia; Schizophrenia

Treatments: Other: Quantitative multiparametric and functional MRI

Study type: Observational

Funder types: Other

Identifiers

NCT02868879

2898

Details and patient eligibility

About

The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways.

The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.

The coherence between structural and functional anomalies will be especially studied.

Enrollment: 162 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria (controls):

• Aged from 18-65 Y
• Right handed

Additional inclusion criteria for patients:

• Schizophrenia according to the DSM5
• Either periodic catatonia or cataphasia according to the WKL classification
• Under stable medication regimen (> 1M)

Exclusion criteria:

• Current substance abuse
• Contraindication to MRI
• Past records susceptible to affect brain integrity
• Severe, unstable medical condition
• Pregnancy
• Patients deprived of their rights

Trial design

162 participants in 2 patient groups

Schizophrenia

Treatment:

Other: Quantitative multiparametric and functional MRI

Normal controls.

Treatment:

Other: Quantitative multiparametric and functional MRI