Androgenetic Alopecia in Fabry Disease

Baylor Scott and White Health (BSWH)

Status: Completed

Conditions: Fabry Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01295008

010-308

Details and patient eligibility

About

The purpose of this study is to assess whether patients with the classic form of Fabry disease have significantly less androgenic alopecia (male pattern baldness).

Full description

Objectives: To test the hypothesis that adult males with classic form of Fabry disease have a significantly lower incidence of androgenic alopecia than matched controls.

Study Population: 120 patients aged 20-64 with Fabry disease that have GLA mutations or alpha-galactosidase A activity associated with no residual enzyme activity and non-Fabry male controls of the same age range and the same number of non-Fabry controls.

Design: This is a cross-sectional study comparing the prevalence of androgenic alopecia in two groups of subjects.

Outcome Measures: The levels of the outcome will be no androgenic alopecia and frontal only androgenetic alopecia opposed to vertex only and frontal and vertex androgenetic alopecia.

Enrollment: 107 patients

Sex: Male

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Male patients with Fabry disease age 20-64 years old.
• Healthy male controls age 20-64 years old
• GLA gene mutations associated with the classic form of Fabry disease or having alpha-galactosidase A activity that is essentially zero
• Patients who freely agree to participate in this study and understand the nature, risks and benefits of this study and give their written informed consent.

Trial design

107 participants in 2 patient groups

Patients with the classic form

Fabry disease and healthy controls