Anemia and Duration of Mechanical Ventilation

Mahidol University

Status: Enrolling

Conditions: Anemia; Organ Dysfunction Syndrome; Critically Ill; Morality; Intensive Care Unit; Mechanical Ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT05382065

255/2565(IRB3)

Details and patient eligibility

About

In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. We aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support >96 hr.

Full description

Anemia is one of the most common conditions encountered critically ill patients. Various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. Anemia can affect cardiopulmonary function as depletion in oxygen content in body. In mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. Some research suggested that hemoglobin level <8.5 g/dl was a potential risk factor for adverse outcome in critically ill patients required mechanical ventilation >96 hr. However, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. To the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. We hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. We, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support >96 hours.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients whose age of equal or more than 18 years old
• Patients admitted to the surgical intensive care unit during the study period
• Patients required ventilatory support with invasive mechanical ventilation for more than 96 hours

Exclusion criteria

• Patients whose data regarding time of beginning or ending of ventilatory support missed
• Patients who are previously included in this study and are re-admitted