Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Unknown

Conditions: Anemia of Acute Inflammation

Study type: Observational

Funder types: Other

Identifiers

NCT01589874

328/2007

Details and patient eligibility

About

Anemia of inflammation (AI), a normochromic, normocytic anemia, associated with abnormal iron utilization, erythropoietin hyporesponsiveness, and decreased red blood cells (RBC) survival is a very common problem in hospitalized patients for acute inflammatory diseases and develops within few days from the onset of illness. Deleterious effects of anemia include increased risk of cardiac related morbidity and mortality in critically ill and older patients.

Anemia is mediated by hepcidin, the 25-amino acid polypeptide hormone that is central to iron trafficking.

Several studies have been performed on pathophysiology of AI in patients affected by chronic diseases but few explore iron metabolism in humans with acute inflammation.

The aim is to develop effective new strategies to detect and manage AI in the setting of acutely ill patients, based on the understanding of iron balance underlying this disorder.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (both):

• serum C-reactive protein level > 3mg/dL
• creatinine level < 2mg/dL (clearance > 30%)

Exclusion Criteria:

• any haematological diseases
• cancer under chemotherapy
• AIDS (or HIV+)
• liver cirrhosis
• genetic hemochromatosis
• immunosuppressive therapy
• blood transfusion in the past 30-days

Trial design

100 participants in 1 patient group

acute ill patients