Anesthesia and Cancer Study: Colon Cancer

Seoul National University

Status: Active, not recruiting

Conditions: Cancer of Colon; Anesthesia

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT04259398

Ane-Can colon (1912-133-109)

Details and patient eligibility

About

This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Full description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Enrollment: 797 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults undergoing surgery to remove colon cancer

Exclusion criteria

• pregnancy
• colon cancer with invasion to perineum
• palliative surgery
• history of diagnosis or surgery for other cancer
• emergent surgery
• ASA PS classification 4 and 5
• refusion to participate in the study
• allergy to anesthetics

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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797 participants in 2 patient groups

TIVA

Experimental group

Description:

propofol infusion targeting bispectral index 40-60

Treatment:

Drug: Propofol

inhalation (Sevoflurane)

Active Comparator group

Description:

sevoflurane targeting bispectral index 40-60

Treatment:

Drug: Sevoflurane