Anesthesia and Cancer Study: Renal Cell Carcinoma

Seoul National University

Status: Active, not recruiting

Conditions: Renal Cell Carcinoma

Treatments: Drug: Propofol; Drug: Inhaled General Anesthetics

Study type: Interventional

Funder types: Other

Identifiers

NCT04503148

Ane-Can Nx

Details and patient eligibility

About

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Full description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Enrollment: 562 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients scheduled for elective nephrectomy due to renal cell carcinoma

Exclusion criteria

• Emergency surgery
• Pregnancy
• Allergies to anesthetics
• Palliative surgery
• Refusal to participate in the study
• History of diagnosis or surgery for other cancer

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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562 participants in 2 patient groups

TIVA group

Experimental group

Description:

Patients receiving the total intravenous anesthesia using propofol

Treatment:

Drug: Propofol

inhalation group

Active Comparator group

Description:

Patients receiving inhalation anesthesia using sevoflurane or desflurane

Treatment:

Drug: Inhaled General Anesthetics