Anesthesia and Motor Evoked Potential (MEP) Recruitment

Cincinnati Children's Hospital Medical Center

Status: Completed

Conditions: Idiopathic Scoliosis

Treatments: Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02199314

2012-1065

Details and patient eligibility

About

Test the hypothesis to recruit larger motor responses to transcranial stimulation.

Full description

The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.

Enrollment: 30 patients

Sex: All

Ages: 12 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 12 through 17 years
• Diagnosis of idiopathic scoliosis
• Scheduled for posterior spinal fusion with neurophysiological monitoring
• No known allergies to propofol or remifentanil
• No contraindication to total intravenous anesthesia
• No contraindications to the administration of volatile agents

Exclusion criteria

• Failure to consent or assent to study
• Diagnosis other than idiopathic scoliosis
• Poorly controlled seizures or the presence of a cochlear implant
• Patient history or family history of malignant hypothermia or mitochondrial myopathies

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

desflurane MEP's

Experimental group

Description:

Transcranial motor evoked potentials are obtained under total intravenous anesthesia (TIVA) and again after desflurane at 3%, for at least 5 minutes.at two different time points. Each subject is his/her own control

Treatment:

Drug: Desflurane