Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers

Ankara City Hospital

Status: Completed

Conditions: Postoperative Complications; Coronary Artery Disease; Anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT06209437

volgaozkan1

Details and patient eligibility

About

The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative complications. The main questions it aims to answer are

• Does the type of anesthesia have a relationship with inflammatory biomarkers?
• Are inflammatory biomarkers associated with postoperative complications?

Full description

This study is planned to be a prospective observational clinical study. Patients who will undergo on-pump coronary artery bypass surgery, meet the eligibility criteria and agree to participate in the study and sign the informed patient consent form will be included in the study.Systemic immune inflammatory index, systemic inflammatory response index, neurophile lymphocyte ratio, platelet lymphocyte ratio will be calculated in the routine complete blood count of patients in the last 3 preoperative days and in the first 24 hours postoperatively.It will be evaluated whether these biomarkers are related to the anesthesia technique used, patients comorbidities and the complications that develop in the first 24 hours postoperatively. Patients will be evaluated preoperatively, intraoperatively and postoperatively; preoperative comorbidities, intraoperative anesthesia management, cross clamp, pump and surgery times, blood and blood product transfusion, inotrope use and complications that develop up to the first 24 hours postoperatively will be recorded.The anesthetic technique to be used will be determined according to the anesthesiologist's preference and will be recorded.

Enrollment: 228 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• On-pump bypass surgery
• Del-Nido cardioplegia used in operation
• ASA (American Society of Anesthesiologists) II- III patients

Exclusion criteria

• Patients with active malignancy
• Diagnosed with systemic inflammatory disease or autoimmune disease
• Chronic liver and kidney disease
• History of cerebrovascular disease within 6 months
• EF (Ejection Fraction) < 45%
• Non-cooperative or patients who do not agree to participate in the study

Trial design

228 participants in 2 patient groups

Inhalation Anesthesia Group

Description:

After induction, anesthesia will be provided with sevoflurane (2.0 mac) and intravenous remifentanil infusion (0.05-0.2 mcg/kg/min). Depth of anesthesia will be evaluated with Bispectral Index (BIS).

Total Intravenous Anesthesia Group

Description:

After induction, anesthesia will be provided with intravenous propofol infusion (50-150 mcg/kg/min) and intravenous remifentanil infusion (0.05-0.2 mcg/kg/min). Depth of anesthesia will be evaluated with Bispectral Index (BIS).