Anesthesia on Optic Nerve Sheath Diameter

Bursa Yüksek İhtisas Education and Research Hospital

Status: Completed

Conditions: Optic Nerve Sheath Diameter

Treatments: Procedure: The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater

Study type: Interventional

Funder types: Other

Identifiers

NCT04407715

2018/11-0

Details and patient eligibility

About

Different amounts of anesthetic gas can be used in the obstetric gynecological surgery operations to be performed with open method. Researchers aimed to compare the effect of gas changes on intraocular nerve diameter by ultrasonography.

Full description

A total of 80 patients who underwent laparotomic gynecological surgery were divided into two groups prospectively: high flow of 2 L/min and minimal flow of 0.5 L/min. Anesthesia was maintained with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 1 (n=40) and with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 2 (n=40). After 10-15 minutes, group 2 was administered minimal flow with 50-60% oxygen-40-50% air at 0.5 L/min and desflurane, and 10 minutes before the end of the surgery, the patients were switched to high flow with 50% oxygen-50% air at 2 L/min.

Enrollment: 80 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-65 years
• ASA I-II
• Who underwent laparotomic gynecological surgery

Exclusion criteria

• Patients with obstructive pulmonary disease
• Patients with decompensated diabetes, those with a fasting period of more than 12 hours -Acute alcohol intoxication
• Chronic alcohol use
• Who refuse to participate in the study
• Who are not cooperative, do not speak Turkish
• Who had known eye disease (glaucoma, retinal detachment), had a previous history of eye surgery,
• Increased intracranial pressure findings (intracranial lesion, previous cerebrovascular diseases
• Body mass index of > 40kg/m2
• ASA > III

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

80 participants in 2 patient groups, including a placebo group

High Flow Anesthesia, Low Flow Anesthesia

Placebo Comparator group

Description:

. The patients were randomly allocated to one of the two groups of fresh gas flows using the closed-envelope technique: 2 L/min high flow and 0.5 L/min minimal flow. Group 1 (n = 40) was operated under high flow anesthesia with 50% O2 - 50% air at 2 L/min and desflurane at 1.1 MAC for the duration of the surgery. For anesthesia maintenance, Group 2 (n=40) was administered 50% oxygen - 50% air at 2 L/min and desflurane for 10-15 minutes. After reaching 1.1 MAC, it was switched to minimal flow with 50-60% oxygen- 40-50% air at 0.5 L/min and desflurane. 10 minutes before the end of the surgery, it was switched to high flow with 50% oxygen -50% air at 2 L/min.

Treatment:

Procedure: The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater

Peroperetive Optic Nerve Sheath Diameter

Active Comparator group

Description:

Optic nerve sheath diameter measurements were performed by an experienced and the same anesthetist. In the measurements, the GE Healthcare Logiq e series USG device and 12-MHz linear probe were used. Longitudinal and transverse axis images were obtained on both eyelids while the patient was in the supine position. Measurements were taken 3 mm behind the optic nerve head

Treatment:

Procedure: The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath Diamater