Anesthesia With Epinephrine in Diabetes Patients is Safe and Effective

University of Sao Paulo General Hospital

Status: Completed

Conditions: Type 2 Diabetes Mellitus; Coronary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02173067

Odonto - Diabetes

Details and patient eligibility

About

The purpose of this study is to investigate the variation in blood glucose levels, hemodynamic effects and patient anxiety score during tooth extraction in type 2 diabetes mellitus with coronary disease patient under local anesthesia with lidocaine 2% with and without epinephrine.

Full description

This is a prospective randomized study including 70 diabetes with coronary disease patients that needed to be submitted to oral surgery. The study was double blind in relation to glycaemia measurements. Continuous monitoring of blood glucose levels for 24 hours was performed using the Minimed Continuous Monitoring System (CGMS, Medtronic). Patientes were randomized into two groups: 35 received 5.4 mL of 2% lidocaine and 35 received 5.4 mL of 2% lidocaine with 1:100,000 epinephrine. In addittion, hemodynamic effects (blood pressure and heart rate) and degree of anxiety were also evaluated.

Enrollment: 70 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Type 2 diabetes mellitus pharmacologically controlled (in use of insulin and/or hypoglycemic agents) Coronary disease -

Exclusion criteria

• Pregnant sepsis acute renal failure

Trial design

70 participants in 2 patient groups

2% lidocaine

Description:

35 patients received 5.4 mL of 2% lidocaine.

2% lidocaine with epinephrine

Description:

35 patients recieved 5.4 mL of 2% lidocaine with 1:100,000 epinephrine.