Anesthetic Advantages of Dexmedetomidine for Hypotensive Anesthesia

Mahidol University

Status: Completed

Conditions: Hypotension; Anesthesia

Treatments: Drug: Dexmedetomidine; Drug: Nitroglycerin

Study type: Interventional

Funder types: Other

Identifiers

NCT02083055

MU-DT/PY-IRB 2012/021.1904

Details and patient eligibility

About

The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive agent compared with nitroglycerin.

Full description

The subject included the healthy patients who underwent orthognathic surgery and gave written the informed consent. The sample size was calculate from the amount of fentanyl use in orthognathic surgical case and difference more 30% was significant. Randomization was done by random number table to 2 groups. Both groups received standardized controlled hypotensive anesthesia and surgery. D group used dexmedetomidine as the hypotensive drug and N group use nitroglycerin. The main outcome were the amount of fentanyl use, time to eye opening, follow simple command, extubation, early postoperative pain, and early postoperative amount of pain killer. All recorded by anesthesiologist on data sheet.

compare statistical analysis used compare mean by unpaired student t test.

Enrollment: 40 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who undergo bimaxillary surgery physical status I according to the classification of the American Society of Anesthesiologist age 18-45 years

Exclusion criteria

• systemic diseases not given informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

dexmedetomidine

Experimental group

Description:

Intraoperative controlled hypotension by dexmedetomidine

Treatment:

Drug: Dexmedetomidine

nitroglycerin

Active Comparator group

Description:

Intraoperative controlled hypotension by nitroglycerin

Treatment:

Drug: Nitroglycerin