Anesthetic Blockades and Migraine

César Fernández-de-las-Peñas

Status and phase: Completed; Phase 2

Conditions: Chronic Migraine; Pain

Treatments: Drug: Anesthetic blockades with bupivacaine; Drug: Isotonic saline injection

Study type: Interventional

Funder types: Other

Identifiers

NCT02188394

HCSC11/263

Details and patient eligibility

About

Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies. The aim of this study is to evaluate the short-term clinical efficacy of GON anaesthetic blockades in chronic migraine and to analyze their effect on pressure pain thresholds (PPTs) in different areas. We hypothesize that those patients receiving real GON anesthetic blockade will receive greater improvements in pain nociception. We will conduct a double-blind, randomized, parallel and placebo-controlled clinical trial where one group will be treated with bilateral GON blockade with bupivacaine 0,5% and the other group will be treated with placebo.

Enrollment: 36 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic migraine

Exclusion criteria

• Other primary headaches
• Other secondary headaches
• Co-morbid medical diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups, including a placebo group

Anesthetic blockades with bupivacaine

Experimental group

Description:

Patients will receive a bilateral greater occipital nerve blockade with bupivacaine 0,5%

Treatment:

Drug: Anesthetic blockades with bupivacaine

Isotonic saline injection

Placebo Comparator group

Description:

Patients will receive a bilateral occipital injection with isotonic saline

Treatment:

Drug: Isotonic saline injection