Anesthetic Effect on Immune Cell in Patients With Cancer

Konkuk University Medical Center

Status: Completed

Conditions: Breast Cancer

Treatments: Drug: Sevoflurane; Drug: propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02758249

KUH1160098

Details and patient eligibility

About

Anesthetics agents has an effect on immune response during the cancer surgery.This influence can regulatory to immune activity or cancer cell survival.

The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Full description

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.

1. immediate before anesthesia induction
2. postoperative 1 hours
3. postoperative 24 hours

Immune cells isolation from patients peripheral blood mononuclear cells. Next, immune cell were co-culture with human cancer cell line (MCF-7) for 24 hours. investigation for immune cell or cancer cell survival by flow cytometry.

Enrollment: 47 patients

Sex: Female

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient who was planned to undergo breast cancer surgery.

Exclusion criteria

• age < 20 years old
• history of hypersensitivity reaction in propofol or sevoflurane
• history of previous cancer
• patient with ongoing inflammation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

---

47 participants in 2 patient groups

sevoflurane

Active Comparator group

Description:

patients under sevoflurane anesthesia

Treatment:

Drug: Sevoflurane

propofol

Active Comparator group

Description:

patients under propofol anesthesia

Treatment:

Drug: propofol