Anesthetic Effect on Immune Cell in Patients With Cancer

K

Konkuk University Medical Center

Status

Completed

Conditions

Breast Cancer

Treatments

Drug: propofol
Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02758249
KUH1160098

Details and patient eligibility

About

Anesthetics agents has an effect on immune response during the cancer surgery.This influence can regulatory to immune activity or cancer cell survival. The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Full description

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order. immediate before anesthesia induction postoperative 1 hours postoperative 24 hours Immune cells isolation from patients peripheral blood mononuclear cells. Next, immune cell were co-culture with human cancer cell line (MCF-7) for 24 hours. investigation for immune cell or cancer cell survival by flow cytometry.

Enrollment

47 patients

Sex

Female

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patient who was planned to undergo breast cancer surgery.

Exclusion criteria

  • age < 20 years old
  • history of hypersensitivity reaction in propofol or sevoflurane
  • history of previous cancer
  • patient with ongoing inflammation

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

Single Blind

47 participants in 2 patient groups

sevoflurane
Active Comparator group
Description:
patients under sevoflurane anesthesia
Treatment:
Drug: Sevoflurane
propofol
Active Comparator group
Description:
patients under propofol anesthesia
Treatment:
Drug: propofol

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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